Indian-Origin Scientist Identifies Dead Probiotic to Cure Leaky Gut

indica News Bureau-


An Indian origin scientist has identified a dead probiotic that can reduce the age-related leaky gut and control harmful, ageing-related inflammation.

A research led by Professor Hariom Yadav and his team was published in the journal GeroScience which revealed that a leaky gut, also known as increased intestinal permeability, is a digestive condition in which bacteria and toxins are able to “leak” through the intestinal wall into the blood stream through holes or cracks in the intestinal lining, causes an increase in low-grade inflammation.

These conditions are common in older people. This syndrome is thought to play a role in the development of many age-related diseases, such as diabetes, obesity, cancer, cardiovascular disease and decline in physical and cognitive functions.

“We know that probiotics are instrumental in maintaining a healthy gut and preventing leakage, but there isn’t much data available to pinpoint which ones work and which ones don’t,” said Yadav, assistant professor of molecular biology at Wake Forest School of Medicine and principal investigator of the study published in the journal GeroScience.

In the study, Yadav’s team first screened eight strains of human-origin probiotics in roundworms, a commonly used model with a short lifespan of 11 to 20 days.

They discovered that a strain of Lactobacillus paracasei (D3-5), even in the non-viable or heat-killed form, extended the roundworms’ life span.

They then tested their initial findings in mice. The results showed that feeding heat-killed D3-5 to older mice prevented high fat diet-induced metabolic dysfunctions, decreased leaky gut and inflammation, and improved physical and cognitive functions.

“Not only did we determine which probiotic strain was the most effective in preventing leaky gut and inflammation, we also showed that the dead version of that probiotic had the same benefits,” Yadav said.

This is the first-of-its kind study to show that a component (lipoteichoic acid) from the cell wall of a dead probiotic induced changes in the gut microbiome and muc in production, thereby reducing leaky gut and inflammation in elderly mice.

“We think our findings could be very useful to the food and supplement industries because dead probiotics have the potential to be more stable and have a longer shelf life than live probiotics, said Yadav, adding, “Determining the strain that is most effective at reducing leaky gut and inflammation would help us target more effective strategies to address the problem, and help explain why probiotics work for some people but not others.”

Yadav has filed a provisional patent application for D3-5.